Efficacy and Safety of Interventions to Control Myopia Progression in Children: An Overview of Systematic Reviews and Meta-Analyses

  • Myopia is a common visual disorder with increasing prevalence.

  • Halting progression of myopia is critical, as high myopia can be complicated by a number of vision-compromising conditions.

  • Forty-four unique primary studies contained in 18 eligible reviews and involving 6400 children were included in the analysis.

  • Results demonstrated the superior efficacy of atropine eyedrops; 1% atropine vs placebo, 0.025 to 0.05% atropine vs control, 0.01% atropine vs control.

  • Atropine was followed by orthokeratology (axial elongation: and novel multifocal soft contact lenses.

  • As regards adverse events, 1% atropine induced blurred near vision (odds ratio [OR] 9.47, [1.17 to 76.78]) and hypersensitivity reactions (OR 8.91, [1.04 to 76.03]).

  • Existing evidence has failed to convince doctors to uniformly embrace treatments for myopic progression control, possibly due to existence of some heterogeneity, reporting of side effects and lack of long-term follow-up.

  • Research geared towards efficient interventions is still necessary.

Publication date

July 25, 2019


BMC Ophthalmology

Sponsor Institution

This research is co-financed by Greece and the European Union (European Social Fund- ESF)


Efthymia Prousali, Anna-Bettina Haidich, Andreas Fontalis, Nikolaos Ziakas, Periklis Brazitikos Asimina Mataftsi
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